Hepatic iron concentration (HIC) is used as a surrogate for total iron balance to guide chelation therapy in transfusion-dependent patients. 1,2 Unfortunately, liver biopsy is invasive and provides only indirect information regarding other organ systems. Biomagnetic susceptibility measurements by superconducting quantum …
In HH, liver iron concentration (LIC) may be up to 10 times the upper limit of normal, where the 95% upper limit of normal is 1.8 mg Fe/g dry tissue . Conditions associated with increased intestinal absorption tend to have preferential liver manifestations due to earlier accumulation in and damage to hepatocytes. Manifestations include liver ...
Magnetic resonance imaging (MRI) is widely recognized as the primary approach to non-invasively determine liver iron concentration (LIC). Over the past 20 …
Introduction. Iron is a necessary component of human physiology. However, excessive iron accumulation may lead to damage due to the formation of toxic free radicals (1-3).Particularly, iron overload in the liver may cause cirrhosis, tissue damage or liver failure ().Quantification of the liver iron concentration (LIC) is indispensable in the …
In conclusion, we have shown that fine-needle aspiration biopsy of the liver can obtain sufficient tissue for biochemical measurement of the hepatic iron concentration in an animal model of iron overload. The clinical applications of fine-needle aspiration liver biopsy in human beings with iron overload is currently being investigated.
Both primary and secondary iron overload can lead to diffuse hepatic iron overload. However, diffuse siderosis is mostly observed in patients receiving multiple blood transfusions. There is a linear correlation between liver …
Background & aims: Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that occasionally progresses to cirrhosis but usually has a benign course. The aim of this study was to investigate the role of the hemochromatosis mutation Cys282Tyr in development of the mild hepatic iron overload found in some patients with NASH and its association …
Background: The quantification of liver iron concentration (LIC) is important for the monitoring of the body iron level in patients with iron overload. Conventionally, LIC is quantified through R2 or R2* mapping using MRI. In this paper, we demonstrate an alternative approach for LIC quantification through measuring the …
MRI is the most widely available and accepted standard of care method for the assessment of liver iron concentration (LIC) as a surrogate biomarker of total body iron content. Three main MRI …
In hyperabsorption syndromes such as thalassemia intermedia or hereditary hemochromatosis, the iron absorption rates fluctuate significantly in response to diet, gastrointestinal acidity, and liver iron concentration (LIC), making it nearly impossible to predict rates of iron accumulation from first principles. 1 In contrast, secondary iron …
Objective: Biochemical measurement of the hepatic iron concentration (HIC) is essential for the diagnosis of hereditary hemochromatosis (HH). The aim of this study was to determine whether the HIC at the time of diagnosis could predict the subsequent phlebotomy requirements and to determine whether saturation of HIC occurred in HH.
Our intention is to demystify the MR quantification of hepatic iron (i.e., the liver iron concentration) and give you a step-by-step approach by answering the most pertinent questions. The following article should be more of a manual or guide for every radiologist than a classic review article, whic …
Liver Iron Concentration; Professional guidelines. PubMed. Iron Chelation Therapy as a Modality of Management. Aydinok Y Hematol Oncol Clin North Am 2018 Apr;32(2):261-275. Epub 2018 Jan 17 doi: 10.1016/j.hoc.2017.12.002. PMID: 29458731. Consequences and management of iron overload in sickle cell disease.
The risk of complications related to fibrosis and cirrhosis increases when there is significant iron overload, which is defined as hepatic iron concentration (HIC) greater than three times the upper limit of normal (greater than 90 micromol/g dry …
Background: Patients with β thalassemia intermedia can have substantial iron overload, irrespectively of their transfusion status, secondary to increased intestinal iron absorption. This study evaluates whether iron overload in patients with β thalassemia intermedia is associated with morbidity. Design and methods: This was a cross-sectional study of 168 …
Measurement of liver iron concentration (LIC) is an important clinical procedure in the management of transfusional iron overload with iron chelation. LIC gives an indication of over- or underchelation. Although chemical assay of needle biopsy samples from the liver has been considered the "gold sta …
Background/aims: Determination of hepatic iron concentration (HIC) is essential for the evaluation of hereditary hemochromatosis. Occasionally, only paraffin-embedded liver biopsy specimens are available, or fresh biopsy specimens have been placed in saline for transport. This study aimed to describe a method for extraction of liver tissue from ...
Hepatic iron concentration (HIC) was determined using MR FerriScan. Unexpectedly, analysis revealed a significant positive correlation between baseline serum adiponectin concentration and HIC, which strengthened after correction for age, , and body mass index (rho = 0.36; P = 0.007). In addition, there were significant inverse …
The majority of people with hereditary hemochromatosis demonstrate a mutation in the HFE gene, which results in decreased production of hepcidin, the protein …
Iron overload can result in liver damage, with the eventual development of cirrhosis, liver failure and hepatocellular carcinoma. Assessment of liver iron levels is necessary for …
Conclusion The liver iron concentration can be accurately quantified based on the 1.5T T 2 * value of the liver and the specific LIC-T 2 * curve equation. 3T T 2 * technology can accurately ...
Iron overload is a systemic disorder and is either primary (genetic) or secondary (exogenous iron administration). Primary iron overload is most commonly associated with hereditary hemochromatosis and secondary iron overload with ineffective erythropoiesis (predominantly caused by β-thalassemia major and sickle cell disease) …
The variability of intra-hepatic iron concentrations can be evaluated using a MR T2* relaxometry method. • Hepatic iron concentration seems to be higher in the IV th segment in cases of higher iron deposition.. To measure liver iron load, a ROI could be placed in segment IV, and not, as in current practice, in the right liver.
The relationship between hepatic iron concentration and SI ratio for each sequence was analyzed with multiple linear regression. Receiver operating characteristic analysis was performed to find the diagnostic thresholds. RESULTS: Sixty-eight patients had normal hepatic iron levels (<36 μmol/g), 23 had hemosiderosis (36–80 μmol/g), …
Our intention is to demystify the MR quantification of hepatic iron (i.e., the liver iron concentration) and give you a step-by-step approach by answering the most pertinent questions. The following …
Measurement of liver iron concentration (LIC) is necessary for a range of iron-loading disorders such as hereditary hemochromatosis, thalassemia, sickle cell disease, aplastic anemia, and myelodysplasia. Currently, chemical analysis of needle biopsy specimens is the most common accepted method of measurement. This study …
Evaluation of hepatic iron concentration (HIC) continues to have an important role in assessing the potential for iron-mediated liver disease in patients with hereditary hemochromatosis (HH).1 Furthermore, HIC monitoring in patients receiving iron chelation therapy is important for patients with hemoglobinopathies (eg, thalassemia, sickle cell …
Purpose: To identify a magnetic resonance (MR) imaging method sufficiently sensitive and specific in the estimation of hepatic iron content to obviate liver biopsy. Materials and methods: Thirty-eight patients underwent percutaneous needle biopsy of the liver with chemical measurement of the hepatic iron concentration and hepatic MR imaging …
They typically occur in cases of severe iron overload, chronic liver disease, and multifactorial conditions (Figs. 2D and 4B). In addition to stainable iron and fibrosis, …
Iron metabolism and overload. Hepatic iron overload is the abnormal and excessive intracellular accumulation of iron in hepatocytes, Kupffer cells, or both hepatocytes and Kupffer cells, primarily as ferritin particles and hemosiderin aggregates 1, 2.Iron overload may occur selectively in the liver but more commonly iron overload is a systemic …
